Aspadol 100 mg tablet, is the brand name for Tapentadol sold worldwide, is not available in generic form. It is an opioid painkiller that acts centrally and has two different modes of action. Aspadol tablets respond more quickly; they start working 30 minutes after taking them.
Both acute and chronic body pain can be treated with its two formulations: Immediate-Release (IR) pills and Extended-Release (ER) tablets.
Formulations
Aspadol's immediate-release pills include a composition that dissolves quickly. Within the first few hours after ingestion, it has a strong analgesic effect due to its quick release in the body.
The Extended-Release (ER) tablet, on the other hand, is made to release the active ingredient, tantadol hydrochloride, gradually over a predetermined amount of time. Compared to the Aspadol IR pills, this enables the analgesic effect to continue longer.
Uses of Aspadol 100 mg tablet
Tapentadol's immediate-release (IR) tablets are used to alleviate pain related to
Migraine, regional pain syndrome, back pain, knee and hip joint pain, dental pain, and post-operative pain.
When it comes to treating pain from fibromyalgia, diabetic neuropathy, and bunionectomy, Extended-Release (ER) tablets are advised.
Physicians also provide clinical recommendations for the use of tapentadol in veterinary species. Being an opioid painkiller, Tapentadol (Aspadol) carries a danger of abuse and dependence, hence it must be used under a doctor's supervision.
Benefits of Aspadol 100 mg tablets
Aspadol is less likely to cause side effects than other opioid analgesics because of its superior safety profile.
Aspadol IR has a 4–6 hour half-life, while Extended-Release (ER) tablets have a 12-hour half-life.
It is often recommended by doctors when other painkillers are ineffective.
Action mechanism of Aspadol tablet
Tapentadol is the first drug licensed by the US FDA that combines noradrenaline reuptake inhibition (NRI) with μ-opioid receptor (MOR) agonism in a single molecule.
While noradrenaline reuptake inhibition (NRI) strengthens the body's inherent pain-inhibiting pathways, μ-opioid receptor (MOR) agonism aids in lowering the pan signal in the brain. Additionally, it functions by attaching itself to a particular brain receptor and changing how the body interprets and reacts to pain.
The primary metabolite of aspadol is Tapentadol-O-Glucuronide, which is produced during liver metabolism. The kidneys perform the elimination, which is dependent on Aspadol's half-life.
Aspadol (Tapentadol) IR has a half-life of 3.93 hours and requires 3.93 hours to be eliminated, while Aspadol ER has a half-life of 4.4 to 5.9 hours and remains in the body for 1.23 days.
Dosage
Aspadol 100mg tablets are approved for use in all medical disorders. Aspadol 100mg IR has a maximum dosage of 600 mg daily, spaced 4–6 hours apart. At 12-hour intervals, the maximum dosage of Aspadol 100mg ER is 500 mg daily. The degree of pain, however, can affect how often the drug is taken.
Patients with sleep apnea may need to adjust their dosage of Aspadol or Tapentadol due to the possibility of sleep-related breathing problems. Take Aspadol 100mg as soon as you remember to take any missing dose. However, if your next dose is almost here, you can skip the missed one and carry on with your usual regimen. To make up for missing a 100 mg dose of Aspadol, do not take two doses.